Long-read sequencing technologies have enabled the sequencing of DNA fragments exceeding 100 kb, significantly advancing the analysis of highly repetitive genomic regions and enabling accurate sequencing of full-length mRNA transcripts - applications that remain challenging for short-read sequencing platforms. At the same time, hybridisation-based target enrichment using complementary probes has proven to be a highly effective strategy for achieving high-depth sequencing of specific genomic regions while reducing overall sequencing costs.
In this webinar, hear about newly developed long-read sequencing methods leveraging target enrichment, with a focus on advanced workflows for long-read DNA methylation analysis and full-length cDNA sequencing. These methods are designed to improve data quality, enhance sequencing efficiency and expand the range of biological applications accessible through long-read technologies.
What You Will Learn:
- Recent advances in long-read sequencing and remaining technical challenges
- Principles and advantages of target enrichment for long-read applications
- Development of long-read–compatible DNA methylation analysis methods
- Target enrichment strategies for full-length cDNA sequencing
- Applications in genomics, epigenomics, and transcriptome research
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