Oncology Research
- DNA/RNA Preservation: Sample collection is the first important step for obtaining high-quality DNA and RNA used in sensitive analyses like NGS and RT-PCR.
- Safe Transport: The DNA/RNA Shield reagent also possesses the remarkable ability to inactivate pathogens including viruses, bacteria, fungi and parasites - making samples safe for handling and transport
- Streamlined Workflow: DNA and RNA can be isolated directly from preserved samples without lengthy precipitation or reagent removal steps.
The MAGicBead™ ctDNA Isolation Kits features a unique, magnetic bead surface chemistry that facilitates unparalleled ctDNA recovery from biofluids. Input volumes can range up to 10mL of plasma. It is compatible with all open automation platforms and a wide range of sample types (serum, saliva, urine, etc.).
- Easy Processing: Included Deparaffinisation Solution for simple paraffin removal. No xylene necessary.
- Improved Recovery: Optimised Proteinase K digestion and heat ensures maximum recovery.
- High Quality: Non-crosslinked DNA and DNA-free RNA are ready for all downstream applications including PCR, Next-Gen Sequencing, etc.
The Maelstrom Switch 8 is an automated nucleic acid extraction system that incorporates TANBead's patented spin-mixing technology to prevent the risk of sample cross-contamination. Designed for versatility, it features interchangeable gearboxes, allowing it to process different sample volumes to meet various needs. The Maelstrom Switch 8 offers customers both convenience and flexibility, making it a valuable tool in the laboratory.
SeraCare’s Seraseq NGS technology provides scalable, flexible and commutable reference materials tailored to the needs of IVD manufacturers, clinical laboratories and oncology research. By combining highly characterised normal or tumour cell lines with engineered biosynthetic DNA and RNA targets it enables the development of highly multiplexed reference standards for a broad range of targeted and comprehensive sequencing panels. This approach enhances assay consistency, improves performance reliability and increases confidence in results for cancer diagnosis, profiling, treatment monitoring and patient stratification.
Next-generation sequencing (NGS) relies on a critical but time-consuming library preparation process that involves DNA fragmentation and adapter ligation. Proper quality control (QC) during this stage is essential for obtaining high-quality data. Agilent provides automated systems for efficient QC, helping laboratories save time and resources while ensuring successful sequencing for various research projects.
The Agilent TapeStation systems is an automated electrophoresis solution for the sample quality control of DNA and RNA samples. The system integrates an instrument, data processing software, reagents and ScreenTape devices specific for DNA and RNA.
The Fragment Analyser systems utilise automated parallel capillary electrophoresis to provide reliable quality control (QC) for nucleic acids. With its unique design and intuitive features, common QC bottlenecks are resolved by the automation of key steps such as gel loading and sample injection increasing lab efficiency.
The Agilent Femto Pulse System offers an excellent solution for analysing high molecular weight DNA samples with high accuracy. Utilising pulsed-field electrophoresis technology, this system delivers precise quantification and qualification of DNA samples up to 165 kb.
The Magnis system provides a complete workflow for NGS library preparation that is fully automated and delivers reproducible results. Built on proven Agilent SureSelect XT HS2 chemistry, start from total RNA with integrated cDNA conversion or unfragmented DNA with onboard enzymatic fragmentation for increased workflow efficiency.
The Bravo NGS offers the advantage of increased throughput and walkaway time without decreasing data quality. The Bravo NGS with on-deck thermal cycler improves the NGS sample preparation workflow with integrated hardware and application protocols while maintaining flexibility for genomics labs requiring application versatility.
This high sensitivity kit is equipped with molecular barcode options to detect low frequency alleles. A total of 384 unique dual indexing allows you to multiplex hundreds of samples and not worry about index hopping.
A true single-shift workflow from samples to enriched libraries enables DNA library prep with enzymatic fragmentation and pre-capture pooling in as little as 6.5 hrs. Compatible with different sequences.
PCR (AMP™)
AMP chemistry was designed to effectively amplify targets even when the quality and quantity of DNA, RNA, or ctDNA are low.
Reagent kits
Tapestri single-cell DNA panels and protein panels can identify co-mutation patterns and zygosity in subclones or cellular identities and subtle cell states.
Cytogenetics Platform
The CytoTerra® Cytogenetics Platform combines the genome-wide structural variation detection power of traditional cytogenetics with the molecular-level precision of chromosomal microarrays and FISH in a single, powerful, NGS-based assay.
SureSelect Cancer CGP assay offers comprehensive genomic profiling for solid tumors. This pan-cancer NGS panel enables detection of somatic variants, including SNVs, CNVs, indels, TLs, gene fusions and the immuno-oncology biomarkers TMB and MSI.
Design
These panels were designed by key thought leaders in clinical cancer research for detecting genetic variants and genomic signatures.
Assays
VARIANTPlex & FUSIONPlex panels can be paired for resource-efficient solutions to provide a flexible CGP solution providing SNVs, indels, ITDs, fusions and expression alterations as needed.
Single-cell DNA sequencing using the Tapestri Platform provides the resolution required to profile thousands of individual cells or nuclei, enabling a much richer characterisation of tumor heterogeneity and clonality.
Enhanced identification of disease-causing genetic variants, using the SureSelect Clinical V4 expertly curated community designs.
Identify SNVs, indels, CNVs and intragenic structural variants in 55 genes relevant for breast, colorectal, endometrial, melanoma, gastric, pancreatic and other inherited cancer research.
The Agilent SureSelect CD HMH myeloid cancer panel has been developed in association with Dr. Ivan Sloma, Associate Professor at the Department of Hematology and Immunology, Henri Mondor University Hospital.
A wide range of panels for different malignancies including large comprehensive panels. ArcherDx panels include FusionPlex (Heme v2, Lymphoma, Myeloid, Pan-Heme) and VariantPlex (Core Myeloid and Myeloid)
Panels
With Mission Bio’s hematology panels, you can simultaneously analyse DNA mutations and protein expression, to discover clonal networks otherwise obfuscated by bulk methods done in parallel. By connecting genotype to phenotype at the single-cell level, you can gain comprehensive insights into disease progression, development of resistance, and minimal residual disease (MRD).
- Detect variants at 0.3% allele frequency with input as low as 10ng
- Sequencing-ready libraries in a single-day workflow (2.5 hours hands-on time)
- Integrated outlier detection and error correction for high sensitivity variant detection
NGS Custom Panels give you the power to target specific genes or genomic regions that matter most to your research.
From bioinformatics and quality control to security, the SeqOne platform manages the entire secondary and tertiary workflow required to produce a clinical-grade genomic report.
Archer Analysis is a versatile bioinformatics platform that streamlines secondary analysis for all Archer assays and is available as a hosted service, or as a locally installed server.
Analyse sequencing data to determine SNV, CNV & protein changes from the same cell simultaneously.
Phase Genomics’ proprietary cloud-based bioinformatic platforms employ novel computational approaches and algorithms to analyse and integrate proximity ligation data.
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