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CLOuD9 Gene Expression Regulation Kit

CLOuD9 is an acronym for Chromatin Loop Reorganization using CRISPR-dCas9. The technology allows for a fully-reversible folding of localized chromatin structure to form a “looping” structure, which enables direct regulation of gene expression, and study of different chromatin-associated proteins and RNAs involved in the process. Innovative—leverage the simplicity of CRISPR/Cas9 targeting—free of DNA cleavage activity—for inducible and reversible chromatin loop formation anywhere in the genome. Well-validated—chromatin loop formation and the resulting changes in gene expression across multiple loci and cell lines is amply demonstrated in Nature Communications paper (Morgan et al. 2017) Broadly applicable—great for studying the role of chromatin in the control of gene expression in a range of areas, including: Developmental biology, Cancer biology, Chromatin structural biology, Chromatin-based therapeutic strategies.

Full kit includes 10μg each of dCas9-PYL1 and dCas9-ABI1 lentivectors and 50μL of 1000X Inducer Agent)

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CLOuD9 Gene Expression Regulation Kit
Catalog Code: CASCL9-100A-KIT
Product Unit: 1 kit POA

1000X Inducer Agent
Catalog Code: CASCL9-200A-1
Product Unit: 200μL POA

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