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EGFR CUTANA CUT&RUN Antibody

Catalog Code: 13-2018Product Unit: 100µL
POA

This antibody meets EpiCypher’s “CUTANA Compatible” criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping. Every lot of a CUTANA Compatible antibody is tested in the indicated approach using EpiCypher optimized protocols (epicypher.com/protocols) and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein. EGFR is a tyrosine kinase receptor for epidermal growth factor (EGF) and other ligands of the EGF family. Activated EGFR can carry out its biological effects via the cytoplasmic pathway or nuclear pathway. The cytoplasmic pathway can cause tumorigenesis, metastasis, high proliferation, and resistance to chemotherapy and radiation.The nuclear pathway causes membrane EGFR to translocate into the nucleus and interact with other DNA-binding transcription factors, which can activate gene expression [1]. EGFR antibody produces CUT&RUN peaks above background (Figure 1) within gene promoters, intronic, and intergenic regions (Figures 1-2).

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