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EZH2 CUTANA CUT&RUN Antibody

Catalog Code: 13-2026Product Unit: 100µL
POA

This antibody meets EpiCypher’s “CUTANA Compatible” criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping. Every lot of a CUTANA Compatible antibody is tested in the indicated approach using EpiCypher optimized protocols (epicypher.com/protocols) and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein. EZH2 catalyzes histone H3 lysine 27 trimethylation (H3K27me3), which leads to transcriptional repression of target genes [1]. EZH2 antibody produces CUT&RUN peaks above background primarily in intronic and intergenic regions (Figure 1) that overlap with H3K27me3 (Figure 2), consistent with its known role as the histone methyltransferase catalytic subunit of the Polycomb Repressive complex 2 (PRC2).

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