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Seraseq ctDNA MRD Panel Mix

Catalog Code: 0710-2146Product Unit: 4 x 20µL (10ng/µL)
$3,804.00 Excl. GST

LGC SeraCare has developed a novel ctDNA MRD mutation mix panel designed to support the development, validation and clinical deployment of ctDNA-based patient-derived MRD monitoring NGS assays. The new Seraseq ctDNA MRD Panel Mix product is constructed from combination of a diseased human cell line, its SNP-matched normal cell line, and biosynthetic DNA containing variants commonly targeted by therapeutic drugs (see list below). The blended DNA is fragmented, sized to mimic ctDNA fragment sizes, and serially diluted to tumor fractions (TF) of 0%, 0.5%, 0.05% and 0.005%.

Combination of diseased human cancer cell line, its SNP-matched normal and biosynthetic DNA variants.
Fragmented, sized (ctDNA), and blended at four tumor levels: 0% (WT), 0.5%, 0.05% and 0.005%.
Develop, validate and routinely determine presence/absence of patient-derived disease variants with high precision (against a matched normal (WT) background).
Variant detection and VAF analysis by digital PCR and targeted cfDNA NGS assay.
Available as a purified DNA mix ready for targeted sequencing library prep.

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