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SMARCA5 Chromatin Remodelling Enzyme

Catalog Code: 15-1024Product Unit: 100 reactions
POA

Full length recombinant human SMARCA5 Remodeling Enzyme. SMARCA5 is a core ATPase subunit of the ATP-dependent chromatin remodeling ISWI complexes that regulate nucleosome spacing to control DNA accessibility. SMARCA5 containing complexes exhibit substrate preference and distinct remodeling directionalities with different regulatory subunit. Mis-regulation of SMARCA5 is linked with multiple human cancers including leukemia, breast, lung, and gastric cancers. SMARCA5 can be used in conjunction with EpiDyne®-FRET Remodeling Assay Substrate (EpiCypher 16-4201) in HTS-compatible drug discovery studies.

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