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SP1 CUTANA CUT&RUN Antibody

Catalog Code: 13-2024Product Unit: 100µL
POA

This antibody meets EpiCypher’s “CUTANA Compatible” criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping. Every lot of a CUTANA Compatible antibody is tested in the indicated approach using EpiCypher optimized protocols (epicypher.com/protocols) and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein. SP1 is the original member of the Sp1-like family of zinc-finger transcription factors. It binds GC-rich motifs with high affinity [1] and is involved in expressing genes related to cell growth, cell-cycle progression, survival, and tumorigenesis [2]. SP1 antibody produces CUT&RUN peaks above background primarily in intronic and promoter regions (Figure 1) that overlap with known SP1 DNA-binding motifs (Figure 2).

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