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Nucleosome, Recombinant Human, H3.1K27me3,S28phos, Biotinylated

EpiCypher

Catalog Code: 16-0397Product Unit: 50µg
POA

Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431; H4-P62805) wrapped by 147 base pairs of 601 positioning sequence DNA containing a 5’ biotin-TEG. The 601 sequence, identified by Lowary and Widom [1], has high affinity for histone octamers and is useful for nucleosome assembly. Histone H3 (created by a proprietary synthetic method) contains trimethyl-lysine at position 27 and phosphoserine at position 28. H3S28 is an essential residue for modulating PRC2-mediated methylation at H3K27me3 [2].

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