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Dinucleosomes, Recombinant Human, Biotinylated

Catalog Code: 16-3004Product Unit: 25µg
POA

Dinucleosomes are comprised of two recombinant octamers (each containing two copies of histone proteins H2A, H2B, H3.1, and H4) positioned on a single, 442 base pair DNA template. Mononucleosomes are the basic repeating unit of chromatin; however, a dinucleosome substrate enables studying longer range chromatin interactions. The DNA contains two 601 positioning sequences (underlined, below) separated by a 60 base pair linker and a 5’ biotin-TEG group. The 601 sequence, identified by Lowary & Widom, has high affinity for histone octamers and is useful for nucleosome assembly.

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